Archive for March 4th, 2008
바이오노빅스와 함께 하셔야 하는 이유
더 많은 정보: 오른쪽에 보이는 “Topics”로 가시면 여러가지 정보를 읽으실 수 있습니다.
바이오노빅스와 함께 하셔야 하는 이유 (블로그주인)
전 일단 세가지로 말씀 드리려 합니다.
1. 건강 2. 돈(성공) 3. 보람된 일 (사회의 건강 증진)
1. 건강
돈을 잃으면 조금 잃은거라고 합니다. 명예를 잃으면 많이 잃은거라고 합니다. 건강을 잃으면 전부 다를 잃은거라고 합니다.
“Topics”에 있는 “체험사례”에서 많은 분들의 MeridiumXN 체험을 듣고, 읽으셨듯이, 잔토휴몰(Xanthohumo)이 우리 몸의 세포와 함께 작용하는그 일은 실로 놀랍습니다. Eric Kuhrts 박사님의 수년간의 연구 및 개발 끝에 탄생한 MeridiumXN. 식물 홉의 꽃에서 추출된 이 잔토휴몰이 물에 쉽게 용해되지 않기 때문에 처음 발견된 것은 20세기 초였으나, 어떠한 제약회사에서도이 물질을 항암치료제로 사용할수 없었습니다. Eric 박사님께서 최초로 이 물질을 체내에 흡수되게끔 발명하시고 구강 투여도 안전실험까지 (참고: “임상실험연구자료”. 총 92가지 실험연구 완료) 거친 후 BioNovix를 통해 이 제품이 나오게 하셨습니다.
의학계 대발명 중 3위를 차지한 잔토휴몰. 우리 몸의 질병을 크게 두가지로 나눈다면, 밖에서 침투해 오는 세균성 질환과 우리 몸 내부에서 발생하는 대사성 질환이 있습니다. 페니실린의 발명으로 세균,박테리아는 통제가 되게 되었으나, 아직까지도 암, 당뇨, 심장질환,우울증 등 대사증후군에 의해 발생하는 대사성질환에 대해선 현대 의학의 큰 과제로 별다른 치료법을 찾지 못한 실정입니다. 하지만 기뻐하십시오.이 대사증후군, 현대의학의 큰 과제가 해결되는 순간이 드디어 찾아왔습니다.
저희 제품 MeridiumXN을 이해하시려면, 대사성 증후군의 모든 것을 이해하셔야 하고 (참고: “대사성 증후군, 비디오”), 잔토휴몰이 우리 몸에서 어떻게 작용을 하여 세포 사이에 끼어 있는 독소,노폐물 및 이물질을 다 분해시켜 자연소멸 혹은 몸 밖으로 방출시키는지에 대해 이해하셔야 합니다. 그리고 더 자세히 알고 싶으신 분은, 왜 우리 세포 사이에 독소및 노폐물이 쌓이게 되어 독을 뿜어내고 몸의 기능을 상실시키는지 “첨가물/자연치유력”을 참고하시면 될 것 같습니다.그 외에도 대사증후군의 원인은 우리 생활의 대부분의 요인, 스트레스, 섭취하는 음식물, 간접흡연, 환경오염, 유전요인 등이될 수가 있구요.
건강으로 인해 절망적인 분들도 처음엔 반신반의하시며 MeridiumXN을 드시기 시작하셨으며, 지금은 그 분들이 “잔토휴몰의 전도사”가 되어 부끄러움도 무릅쓴 채 만나는 분들마다 이 소식을 전하고 계십니다. “체험사례” 참고해 주세요. 여러분, 더이상 홍수같이 우리에게 쏟아져 나오는 건강식품으로 인해 식상해 하실 필요가 없습니다. 드디어 여러분을 대 혼란에서 구해 줄 MeridiumXN, Xanthohumol이 여러분에게 인사 드리게 되었습니다.
2. 돈
많은 네트워크 마케팅 비지니스 기회가 나와 있다고 합니다. 제가 아는건 허벌라이프, 아메이밖에 없지만요. 솔직히 제가 정말 모든이들의 건강”만”을 위해 이 비지니스에 뛰어들었다면, 그건 뻔한 거짓말일테죠. 동기는 반드시 한가지만 될 필요는 없습니다. 그리고 우리 모두가, 그리고 여러분들이 이민오셔서 (혹은 한국에서도) 열심히 피땀 흘려 일하시는 이유도, 가족을 부양하고 풍요로운 삶을 살며, 자녀들 교육 시키고 노후를 보장하기 위함 아닌가요? 열심히 돈을 벌어 경제적 압박감에서 벗어나 성공을 이루고 싶으시다면, 이왕 같은 돈을 버는거, 바이오노빅스를 통해 하시지 않으시겠습니까? 그냥 돈을 버는 것이 아닙니다. 실질적인 건강증진을 도모하며, 여러분들이 생사갈림길에 놓여 있는 수많은 분들에게 새 생명을 선물하시는 것이 됩니다. 같은 돈을 버는 것, 진실된 회사, 진실된 제품, 튼튼한 의학계/과학계 실험 연구 및 개발, 특허로 보호받고 있는, MeridiumXN, MeridiumXH, Ejuvinate과 함께 하시지 않으시겠습니까? 가짜가 진짜같기만한 가짜천국시대에 부디 여러분들께서 바이오노빅스 회사와 그 제품의 진실을 알아 주시길 원합니다. (많은 정보가 오른쪽 “Topics” 안에 올려져 있으니 가서 참고하세요). 제가 살고있는 시애틀, 워싱턴 지역에서, 이 exciting한 건강 사업을 함께 펼쳐나갈 사업자분들을 찾고 있습니다.저 혼자의 힘보다는, 두사람이, 세사람이, 열사람이 모여 함께 이루어 간다면, synergy의 힘으로 물질적 성공도 2배, 3배, 6배 더 효과적으로 창출해낼수 있을거라 믿고 있습니다. 특히, 캐나다,일본,홍콩에도 올해 안에 오픈할 예정인 것으로 알고 있습니다 (공식적발표아님). 시애틀 지역에 계신 분들과 함께, 바로위 밴쿠버 BC도 확장해 나가길 원합니다. 그냥 넘어가시기엔, 잔토휴몰의 파워와, 바이오노빅스의 잠재성이 너무 아쉽기만 하네요.
3. 보람된 일 (사회 건강 증진)
위에서 말씀드린 바와 같이, 같은 돈을 버는 것이지만, 남을 위해 실컷 일을 하여 버는 돈이 있고, illegal 행위로 버는 돈이 있는가 하면 사회에 기여하며 보람된 일로 버는 돈이 있습니다. 저도 샐러리맨(남을위해일하고 버는 돈)으로써, 남을 위해 일하는 것이 질이 떨어진다는 말씀을 드리는 것이 절대로 아닙니다. 어떻게 수입을 얻든, 중요한 것은 떳떳하게 벌어, 어떠한 형태로든 사회에 공헌이 되고 도움이 될 때에, 더 보람을 느끼며 살기 좋은 곳이 되지 않을까..하는 저의 짧은 생각입니다.
감히 말씀 드립니다. 바이오노빅스와 함께 건강 사업을 하시며, 건강의 축복도, 물질의 축복도 모두 누리실 수 있기를 바랍니다. 그리고 이 기쁜 소식, 암.당뇨.심장질환 및 모든 대사증후군의 결과의 해결책 MeridiumXN을 함께 알리며, 주위의 분들의 건강 또한 증진시켜 드리고, 아픔과 기쁨을 함께 나누고자, 여러분들께 이 건강사업 기회를 소개해 드렸습니다.
이제 선택은 여러분들께 있습니다. 문의가 있으시면, 저에게 연락 주세요. Contact로 가시면 제 정보가 있습니다. 감사합니다. 그리고 하시는 모든 일 위에 하늘의 축복이 있길 바랍니다.
최한나 올림
Bone Resoprtion Inhibitors from Hop Extract, Xanthohumols
-
Biosci Biotechnol Biochem. 1997 Jan;61(1):158-9.
-
Bone resorption inhibitors from hop extract.
Pharma Research and Development Division, Hoechst Japan Limited, Saitama, Japan.
We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC50 (concentration of 50% inhibition) value was 5.9 x 10(-9)M.
PMID: 9028043 [PubMed – indexed for MEDLINE]
Xanthohumols, DA inhibitors from Hops.
-
Phytochemistry. 1997 Oct;46(4):683-7.
-
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus.
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
A methanol extract of hops of Humulus lupulus (L.) showed inhibitory activity against rat liver diacylglycerol acyltransferase (DGAT). From DGAT inhibitory activity-guided fractionation, two chalcones were isolated. One was identified as xanthohumol and the other was found to be a new product designated xanthohumol B. The structure of xanthohumol B was shown to be 6-[3,4-dihydro-3,5-dihydroxy-7-methoxy-2,2-dimethyl-2H-benzo[b]pyrano ]- 3-(4-hydroxyphynyl)-2-propen-l-one by spectroscopic studies including various NMR measurements. Xanthohumol and xanthohumol B inhibited DGAT activity with IC50 values of 50.3 and 194 microM in rat liver microsomes, respectively. They showed preferential inhibition of triacylglycerol formation in intact Raji cells, indicating that they inhibit DGAT activity preferentially in living cells.
PMID: 9366096 [PubMed – indexed for MEDLINE]
Xanthohumol in Human Cancer Cells
-
Food Chem Toxicol. 1999 Apr;37(4):271-85.
-
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA.
Six flavonoids [xanthohumol (XN), 2′,4′,6′,4-tetrahydroxy-3′-prenylchalcone (TP); 2′,4′,6′,4-tetrahydroxy-3′-geranylchalcone (TG); dehydrocycloxanthohumol (DX); dehydrocycloxanthohumol hydrate (DH); and isoxanthohumol (IX)] from hops (Humulus lupulus) were tested for their antiproliferative activity in human breast cancer (MCF-7), colon cancer (HT-29) and ovarian cancer (A-2780) cells in vitro. XN, DX and IX caused a dose-dependent (0.1 to 100 microM) decrease in growth of all cancer cells. After a 2-day treatment, the concentrations at which the growth of MCF-7 cells was inhibited by 50% (IC50) were 13.3, 15.7 and 15.3 microM for XN, DX and IX, respectively. After a 4-day treatment, the IC50 for XN, DX and IX were 3.47, 6.87 and 4.69 microM, respectively. HT-29 cells were more resistant than MCF-7 cells to these flavonoids. In A-2780 cells, XN was highly antiproliferative with IC50 values of 0.52 and 5.2 microM after 2 and 4 days of exposure, respectively. At 100 microM, all the hop flavonoids were cytotoxic in the three cell lines. Growth inhibition of XN- and IX-treated MCF-7 cells was confirmed by cell counting. XN and IX inhibited DNA synthesis in MCF-7 cells. As antiproliferative agents, XN (chalcone) and IX (flavanone isomer of XN) may have potential chemopreventive activity against breast and ovarian cancer in humans.
PMID: 10418944 [PubMed – indexed for MEDLINE]
Prenylated Chalcones and Flavanones
-
Cancer Lett. 2000 Feb 28;149(1-2):21-9.
-
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells.
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis 97331, USA.
The objective of this study was to determine if prenylchalcones (open C-ring flavonoids) and prenylflavanones from hops and beer are inducers of quinone reductase (QR) in the mouse hepatoma Hepa 1c1c7 cell line. All the prenylchalcones and prenylflavanones tested were found to induce QR but not CYP1A1 in this cell line. In contrast, the synthetic chalcone, chalconaringenin, and the flavanone, naringenin, with no prenyl or geranyl groups, were ineffective in inducing QR. The hop chalcones, xanthohumol and dehydrocycloxanthohumol hydrate, also induced QR in the Ah-receptor-defective mutant cell line, Hepa 1c1c7 bp(r)c1. Thus, the prenylflavonoids represent a new class of monofunctional inducers of QR.
PMID: 10737704 [PubMed – indexed for MEDLINE]
Antioxidant and Prooxidant Actions of Cahlcones and Flavanones
-
J Agric Food Chem. 2000 Sep;48(9):3876-84.
-
Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro.
Department of Environmental and Molecular Toxicology, Department of Chemistry, Linus Pauling Institute, Corvallis, Oregon, USA.
Prenylated flavonoids found in hops and beer, i.e., prenylchalcones and prenylflavanones, were examined for their ability to inhibit in vitro oxidation of human low-density lipoprotein (LDL). The oxidation of LDL was assessed by the formation of conjugated dienes and thiobarbituric acid-reactive substances (TBARS) and the loss of tryptophan fluorescence. At concentrations of 5 and 25 microM, all of the prenylchalcones tested inhibited the oxidation of LDL (50 microg protein/ml) induced by 2 microM copper sulfate. The prenylflavanones showed less antioxidant activity than the prenylchalcones, both at 5 and 25 microM. At 25 microM, the nonprenylated chalcone, chalconaringenin (CN), and the nonprenylated flavanone, naringenin (NG), exerted prooxidant effects on LDL oxidation, based on TBARS formation. Xanthohumol (XN), the major prenylchalcone in hops and beer, showed high antioxidant activity in inhibiting LDL oxidation, higher than alpha-tocopherol and the isoflavone genistein but lower than the flavonol quercetin. When combined, XN and alpha-tocopherol completely inhibited copper-mediated LDL oxidation. These findings suggest that prenylchalcones and prenylflavanones found in hops and beer protect human LDL from oxidation and that prenylation antagonizes the prooxidant effects of the chalcone, CN, and the flavanone, NG.
PMID: 10995285 [PubMed – indexed for MEDLINE]
The Chalcone Xanthohumol’s Functions
-
J Nutr. 2004 Jun;134(6):1340-6.
-
The chalcone xanthohumol inhibits triglyceride and apolipoprotein B secretion in HepG2 cells.
Division of Medical Technology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, Hawaii.
The present study examined the role of xanthohumol (XN), a plant chalcone, on apolipoprotein B (apoB) and triglyceride (TG) synthesis and secretion, using HepG2 cells as the model system. The data indicated that XN decreased apoB secretion in a dose-dependent manner under both basal and lipid-rich conditions (as much as 43% at 15 micromol/L). This decrease was associated with increased cellular apoB degradation. To determine the mechanism underlying this effect, we examined triglyceride availability, a major factor in the regulation of apoB secretion. XN inhibited the synthesis of TG in the microsomal membrane and the transfer of this newly synthesized TG to the microsomal lumen (decreases of 26 and 64%, respectively, under lipid-rich conditions), indicating that TG availability is a determining factor in the regulation of apoB secretion under the experimental conditions. The inhibition of TG synthesis was caused by a reduction in diacylglycerol acyltransferase (DGAT) activity, which corresponded to a decrease in DGAT-1 mRNA expression, but not DGAT-2 expression. Microsomal triglyceride transfer protein (MTP) may also control the rate of TG transfer from the microsomal membrane to the active lumenal pool. XN decreased MTP activity in a dose-dependent manner (as much as 30%). Whether the reduction in TG accumulation in the microsomal lumen is predominantly due to DGAT and/or MTP activity remains unknown. In summary, the data suggest that xanthohumol is a potent inhibitor of apoB secretion.
PMID: 15173394 [PubMed – indexed for MEDLINE]
Xanthohumol from Hops and Beer: To Your Good Health!
-
Phytochemistry. 2004 May;65(10):1317-30.
-
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
Department of Chemistry and the Linus Pauling Institute, Oregon State University, 117 Weniger Hall, Corvallis, OR 97331, USA. fred.stevens@oregonstate.edu
Xanthohumol (3′-[3,3-dimethyl allyl]-2′,4′,4-trihydroxy-6′-methoxychalcone) is the principal prenylated flavonoid of the female inflorescences of the hop plant (‘hops’), an ingredient of beer. Human exposure to xanthohumol and related prenylflavonoids, such as 8-prenylnaringenin and isoxanthohumol, is primarily through beer consumption. Xanthohumol has been characterized a ‘broad-spectrum’ cancer chemopreventive agent in in vitro studies, while 8-prenylnaringenin enjoys fame as the most potent phytoestrogen known to date. These biological activities suggest that prenylflavonoids from hops have potential for application in cancer prevention programs and in prevention or treatment of (post-)menopausal ‘hot flashes’ and osteoporosis. Xanthohumol and 8-prenylnaringenin are metabolized into many flavonoid derivatives with modified 3,3-dimethyl allyl (prenyl) moieties. Xanthohumol is formed in lupulin glands by a specialized branch of flavonoid biosynthesis that involves prenylation and O-methylation of the polyketide intermediate chalconaringenin. Although a lupulin gland-specific chalcone synthase is known, the aromatic prenyltransferase and O-methyltransferase participating in xanthohumol have not been identified. The prenylflavonoid pathway is a possible target for breeding or biotechnological modification of hops with the aim of increasing xanthohumol levels for beer brewing and 8-prenylnaringenin levels for pharmaceutical production. Copyright 2004 Elsiever Ltd.
PMID: 15231405 [PubMed – indexed for MEDLINE]
Xanthohumol, a novel anti-HIV-1 Agent
-
Antiviral Res. 2004 Dec;64(3):189-94.
-
Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus.
Laboratory of Molecular Immunopharmacology, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China.
Xanthohumol, prenylchacone flavonoid, is a natural product with multi-biofunctions purified from Hops Humulus lupulus. Its anti-HIV-1 activity was tested in the present study. Results showed that xanthohumol inhibited HIV-1 induced cytopathic effects, the production of viral p24 antigen and reverse transcriptase in C8166 lymphocytes at non-cytotoxic concentration. The EC50 values were 0.82, 1.28 and 0.50 microg/ml, respectively. The therapeutic index (TI) was about 10.8. Xanthohumol also inhibited HIV-1 replication in PBMC with EC50 value of 20.74 microg/ml. The activity of recombinant HIV-1 reverse transcriptase and the HIV-1 entry were not inhibited by xanthohumol. The results from this study suggested that xanthohumol is effective against HIV-1 and might serve as an interesting lead compound. It may represent a novel chemotherapeutic agent for HIV-1 infection. However, the mechanism of its anti-HIV-1 effect needs to be further clarified.
PMID: 15550272 [PubMed – indexed for MEDLINE]
Xanthohumol’s Enhanced Antitumor Activity
-
Cancer Lett. 2005 Mar 10;219(2):215-22.
-
Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia.
Department of Medical Biochemistry and COE Program in the 21st Century, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan.
Cancer chemotherapy for hypoxic tumor cells is thought to be an important issue, since hypoxia is related to tumor growth, apoptosis, angiogenesis and metastasis. Here, the bioactivities of xanthohumol (XN), a diacylglycerol acyltransferase inhibitor, against hypoxic cells were investigated. At first, the inhibitory effects of XN on the formation of lipid droplets in the cytoplasm were evaluated in hypoxia. Hypoxia upregulated the synthesis of triglyceride and promoted the formation of lipid droplets in the cytoplasm, however, the treatment of XN downregulated the triglyceride synthesis and completely canceled the appearance of lipid droplets. Second, the effects of XN on the proliferation and the motility of HT-1080 human fibrosarcoma were investigated. The proliferation of HT-1080 was significantly suppressed in the presence of XN only in hypoxic condition but not in normoxic condition. XN also suppressed the motility of HT-1080 that was enhanced by hypoxia. Since, most cells in solid tumor were thought to be in hypoxic condition and acquired malignancy in response to hypoxia, these data suggest that XN may have potent and specific activities against cancerous cells. Furthermore, these data suggested that lipid metabolism may play an important role for hypoxic tumor cells and proposed a new therapeutic target for cancer chemotherapy.
PMID: 15723722 [PubMed – indexed for MEDLINE]
대사성 증후군/사업 기회
더 많은 정보: 오른쪽 “Topics”로 가시면 더 많은 정보를 읽으실 수 있습니다.
대사증후군/사업기회
아래를 눌러 주시면, Joshua Park 사장님께서 직접 만드신 프레전테이션 형태의 대사증후군에 대해 요약 된 내용 및 간략한 사업 기회에 대해서 읽으실 수 있습니다.
Read Full Post | Make a Comment ( None so far )
One Molecule (XN) is About to Change Your World (English & Korean) 