Research
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There are approximately 90 studies on Xanhohumol (XN) which have been successfully researched and experiments conducted by scientists and medical/biochemical researchers throughout the world. Reference: www.pubmed.gov (and enter “Xanthohumol” for your search.
Xanthohumol The Master Molecule
Researchers at Oregon State University, working with micronutrients found in the flower of the hops plant, isolated a single molecule capable of dramatically reducing an individual’s level of oxidative stress.
Scientists are discovering that this molecule, known as Xanthohumol (XN), has several unique effects and exhibits a broad spectrum of biological activities. Along with inhibiting tumor growth and enzymes that activate cancer cells, it also helps the body make unhealthy compounds more water-soluble, so they can be excreted.
The health benefits of this “master- molecule” have been known for years, and in more than 60 research studies it has been linked to a wide range of potential benefits:
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Supports cell health to fight oxidative stress
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Regulates fat metabolism and storage
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Modulates cholesterol and triglyceride levels
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Promotes general health to ward off illness
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Supports eye cornea and retina health
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Maintains glucose and insulin levels
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Protects against free radicals better than green tea and red wine, with 6 times the power of antioxidant-rich citrus fruits and 4 times the strength of soy foods, also high in antioxidants
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Eliminates toxins from the body
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Modulates the hormone responsible for a sense of well-being
The following list presents selected published research on the bioactive properties of xanthohumol.
The bibliography includes the author(s), article name, the journal in which the article was published, and the date of publication. Furthermore, we have provided the PubMed ID number (PMID) for each article.
PubMed is an online database developed by the National Center for Biotechnology Information (NCBI) at the National Library of Medicine (NLM) located at the U.S. National Institutes of Health (NIH). Additional information on each article can be obtained by clicking on the links below or by going to www.pubmed.gov and entering the PMID into the search box provided on the website.
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Delmulle L, Bellahcene A, Dhooge W, Comhaire F, Roelens F, Huvaere K, Heyerick A, Castronovo V, De Keukeleire D.
Anti-proliferative properties of prenylated flavonoids from hops (Humulus lupulus L.) in human prostate cancer cell lines.
Phytomedicine. 2006 May 4; PMID: 16678392
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Colgate EC, Miranda CL, Stevens JF, Bray TM, Ho E.
Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells.
Cancer Lett. 2006 Mar 22; PMID: 16563612 -
Albini A, Dell’Eva R, Vene R, Ferrari N, Buhler DR, Noonan DM, Fassina G.
Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-kappaB and Akt as targets.
FASEB J. 2006 Mar; 20(3):527-9. PMID: 16403733 -
Lust S, Vanhoecke B, Janssens A, Philippe J, Bracke M, Offner F.
Xanthohumol kills B-chronic lymphocytic leukemia cells by an apoptotic mechanism.
Mol Nutr Food Res. 2005 Sep;49(9):844-50. PMID: 16144030 -
Gerhauser C, Frank N.
Xanthohumol, a new all-rounder?
Mol Nutr Food Res. 2005 Sep;49(9):821-3. PMID: 16144029 -
Nozawa H.
Xanthohumol, the chalcone from beer hops (Humulus lupulus L.), is the ligand for farnesoid X receptor and ameliorates lipid and glucose metabolism in KK-A(y) mice.
Biochem Biophys Res Commun. 2005 Oct 28;336(3):754-61. PMID: 16140264 -
Dietz BM, Kang YH, Liu G, Eggler AL, Yao P, Chadwick LR, Pauli GF, Farnsworth NR, Mesecar AD, van Breemen RB, Bolton JL.
Xanthohumol isolated from Humulus lupulus inhibits menadione-induced DNA damage through induction of quinone reductase.
Chem Res Toxicol. 2005 Aug;18(8):1296-305. PMID: 16097803 -
Gerhauser C.
Broad spectrum anti-infective potential of xanthohumol from hop (Humulus lupulus L.) in comparison with activities of other hop constituents and xanthohumol metabolites.
Mol Nutr Food Res. 2005 Sep;49(9):827-31. PMID: 16092071 -
Hussong R, Frank N, Knauft J, Ittrich C, Owen R, Becker H, Gerhauser C.
A safety study of oral xanthohumol administration and its influence on fertility in Sprague Dawley rats.
Mol Nutr Food Res. 2005 Sep;49(9):861-7. PMID: 16092070 -
Hanske L, Hussong R, Frank N, Gerhauser C, Blaut M, Braune A.
Xanthohumol does not affect the composition of rat intestinal microbiota.
Mol Nutr Food Res. 2005 Sep;49(9):868-73. PMID: 16092067 -
Pan L, Becker H, Gerhauser C.
Xanthohumol induces apoptosis in cultured 40-16 human colon cancer cells by activation of the death receptor- and mitochondrial pathway.
Mol Nutr Food Res. 2005 Sep;49(9):837-43. PMID: 15995977 -
Vanhoecke B, Derycke L, Van Marck V, Depypere H, De Keukeleire D, Bracke M.
Antiinvasive effect of xanthohumol, a prenylated chalcone present in hops (Humulus lupulus L.) and beer.
Int J Cancer. 2005 Dec 20;117(6):889-95. PMID: 15986430 -
Gerhauser C.
Beer constituents as potential cancer chemopreventive agents.
Eur J Cancer. 2005 Sep;41(13):1941-54. Review. PMID: 15953717 -
Frolich S, Schubert C, Bienzle U, Jenett-Siems K.
In vitro antiplasmodial activity of prenylated chalcone derivatives of hops (Humulus lupulus) and their interaction with haemin.
J Antimicrob Chemother. 2005 Jun;55(6):883-7. PMID: 15824094 -
Goto K, Asai T, Hara S, Namatame I, Tomoda H, Ikemoto M, Oku N.
Enhanced antitumor activity of xanthohumol, a diacylglycerol acyltransferase inhibitor, under hypoxia.
Cancer Lett. 2005 Mar 10;219(2):215-22. PMID: 15723722 -
Wang Q, Ding ZH, Liu JK, Zheng YT.
Xanthohumol, a novel anti-HIV-1 agent purified from Hops Humulus lupulus.
Antiviral Res. 2004 Dec;64(3):189-94. PMID: 15550272 -
Stevens JF, Page JE.
Xanthohumol and related prenylflavonoids from hops and beer: to your good health!
Phytochemistry. 2004 May;65(10):1317-30. PMID: 15231405 -
Casaschi A, Maiyoh GK, Rubio BK, Li RW, Adeli K, Theriault AG.
The chalcone xanthohumol inhibits triglyceride and apolipoprotein B secretion in HepG2 cells.
J Nutr. 2004 Jun;134(6):1340-6. PMID: 15173394 -
Buckwold VE, Wilson RJ, Nalca A, Beer BB, Voss TG, Turpin JA, Buckheit RW 3rd, Wei J, Wenzel-Mathers M, Walton EM, Smith RJ, Pallansch M, Ward P, Wells J, Chuvala L, Sloane S, Paulman R, Russell J, Hartman T, Ptak R.
Antiviral activity of hop constituents against a series of DNA and RNA viruses.
Antiviral Res. 2004 Jan;61(1):57-62. PMID: 14670594 -
Gerhauser C, Alt A, Heiss E, Gamal-Eldeen A, Klimo K, Knauft J, Neumann I, Scherf HR, Frank N, Bartsch H, Becker H.
Cancer chemopreventive activity of Xanthohumol, a natural product derived from hop.
Mol Cancer Ther. 2002 Sep;1(11):959-69. PMID: 12481418 -
Miranda CL, Stevens JF, Ivanov V, McCall M, Frei B, Deinzer ML, Buhler DR.
Antioxidant and prooxidant actions of prenylated and nonprenylated chalcones and flavanones in vitro.
J Agric Food Chem. 2000 Sep;48(9):3876-84. PMID: 10995285 -
Miranda CL, Aponso GL, Stevens JF, Deinzer ML, Buhler DR.
Prenylated chalcones and flavanones as inducers of quinone reductase in mouse Hepa 1c1c7 cells.
Cancer Lett. 2000 Feb 28;149(1-2):21-9. PMID: 10737704 -
Miranda CL, Stevens JF, Helmrich A, Henderson MC, Rodriguez RJ, Yang YH, Deinzer ML, Barnes DW, Buhler DR.
Antiproliferative and cytotoxic effects of prenylated flavonoids from hops (Humulus lupulus) in human cancer cell lines.
Food Chem Toxicol. 1999 Apr;37(4):271-85. PMID: 10418944 -
Tabata N, Ito M, Tomoda H, Omura S.
Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus.
Phytochemistry. 1997 Oct;46(4):683-7. PMID: 9366096 -
Tobe H, Muraki Y, Kitamura K, Komiyama O, Sato Y, Sugioka T, Maruyama HB, Matsuda E, Nagai M.
Bone resorption inhibitors from hop extract.
Biosci Biotechnol Biochem. 1997 Jan;61(1):158-9. PMID: 9028043
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