Bone Resoprtion Inhibitors from Hop Extract, Xanthohumols

Posted on March 4, 2008. Filed under: Research | Tags: , , , , , , |

Biosci Biotechnol Biochem. 1997 Jan;61(1):158-9.

Bone resorption inhibitors from hop extract.

Tobe H, Muraki Y, Kitamura K, Komiyama O, Sato Y, Sugioka T, Maruyama HB, Matsuda E, Nagai M.

Pharma Research and Development Division, Hoechst Japan Limited, Saitama, Japan.

We searched hop extract for active component(s) that inhibited bone resorption in the pit formation assay, and isolated xanthohumol and humulone as active ingredients. Especially humulone had extraordinarily strong inhibitory activity and the IC50 (concentration of 50% inhibition) value was 5.9 x 10(-9)M.

PMID: 9028043 [PubMed - indexed for MEDLINE]

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